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KMID : 0367320050160020279
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2005 Volume.16 No. 2 p.279 ~ p.285
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AN OBSERVATIONAL MULTI-CENTER STUDY FOR EVALUATION OF EFFICACY, SAFETY AND PARENTAL SATISFACTION OF METHYLPHENIDATE-OROS IN CHILDREN WITH ADHD
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Kim Bong-Seog
Park Eun-Jin
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Abstract
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Objectives: This study was performed to evaluate the efficacy and safety of MPH-OROS and parental satisfaction for treatment of children with ADHD
Method: The 569 participants were clinically diagnosed for ADHD using DSM-IV criteria. We switched current medication to MPH-OROS or introduced MPH-OROS for treatment of ADHD. We assessed the clinical global impression severity of illness (CGI-S), the clinical global impression severity of improvement(CGI-I). And the parents of participants measured the Korean version of Conners rating scale at baseline, the 1 st week and the 3rd week after MPH-OROS trial. At the 3rd week, the parents measured the parent satisfaction questionnaire.
Results: 13% of participants dropped out because of several causes including side effects. The change of CGI-S was significantly decreased. Using CGI-I, the improvement was 72.3% at the 1st week and 87.4% at the 3rd week. The total score of the Korean version of Conners parent rating scale was significantly decreased. The participants complaining one or more of side effects were 119(20.7%), and the most common side effect was anorexia. The 94% of parents replied that they were overall satisfied with MPH-OROS trial. Also the advantages of MPH-OROS of parental report were the long duration of the drug, the improvement of schoolwork and attitude, the improvement of home behavior and homework and the improvement of overactivity.
Conclusion: MPH-OROS is effective and well-tolerated in actual clinical use for ADHD.
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KEYWORD
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ADHD, MPH-OROS, Efficacy, Safety, Parental satisfaction
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